SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* SR One Capital Fund I Aggregator LP (Last) (First) (Middle) 985 OLD EAGLE SCHOOL ROAD, SUITE 511 (Street) WAYNE PA 19087 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Design Therapeutics, Inc. [ DSGN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 03/30/2021
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	03/30/2021		C		4,439,839	A	(1)	4,439,839	D(2)
Common Stock	03/30/2021		C		936,637	A	(1)	5,376,476	D(2)
Common Stock	03/30/2021		P(3)		250,000	A	$20	5,626,476	D(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(1)	03/30/2021		C			7,236,938	(1)	(1)	Common Stock	4,439,839	$0.00	0	D(2)
Series B Preferred Stock	(1)	03/30/2021		C			1,526,718	(1)	(1)	Common Stock	936,637	$0.00	0	D(2)

1. Name and Address of Reporting Person* SR One Capital Fund I Aggregator LP (Last) (First) (Middle) 985 OLD EAGLE SCHOOL ROAD, SUITE 511 (Street) WAYNE PA 19087 (City) (State) (Zip)

1. Name and Address of Reporting Person* SR ONE CAPITAL PARTNERS I, LP (Last) (First) (Middle) 985 OLD EAGLE SCHOOL ROAD, SUITE 511 (Street) WAYNE PA 19087 (City) (State) (Zip)

1. Name and Address of Reporting Person* SR ONE CAPITAL MANAGEMENT, LLC (Last) (First) (Middle) 985 OLD EAGLE SCHOOL ROAD, SUITE 511 (Street) WAYNE PA 19087 (City) (State) (Zip)

Explanation of Responses:

1. The Series A Preferred Stock and the Series B Preferred Stock were converted into Common Stock on a 1.63-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A Preferred Stock and Series B Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

2. The reported securities are held directly by SR One Capital Fund I Aggregator, LP. SR One Capital Partners I, LP is the general partner of SR One Capital Fund I Aggregator, LP, and SR One Capital Management, LLC is the general partner of SR One Capital Partners I, LP. Simeon George, M.D. is the managing member of SR One Capital Management, LLC. Each of SR One Capital Partners I, LP, SR One Capital Management, LLC and Mr. George may each be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

3. SR One Capital Fund I Aggregator, LP purchased 250,000 shares of Common Stock of Design Therapeutics, Inc. (the "Issuer") in connection with the Issuer's public offering.

Remarks:

	SR ONE CAPITAL FUND I AGGREGATOR, LP, By: SR ONE CAPITAL PARTNERS I, LP, its General Partner, By: SR ONE CAPITAL MANAGEMENT, LLC, its General Partner, By: /s/ Simeon George, Member	03/31/2021
	SR ONE CAPITAL PARTNERS I, LP, By: SR ONE CPAITAL MANAGEMENT, LLC, By: /s/ Simeon George, Member	03/31/2021
	SR ONE CAPITAL MANAGEMENT, LLC, By: /s/ Simeon George, Member	03/31/2021
	** Signature of Reporting Person	Date
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